Indicated for adult patients prone to intra-abdominal bacterial infection & antibiotic associated diarrhoea.
Doxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals). Lactobacillus is a probiotic. It is used along with antibiotics in order to restore the body`s natural microbial flora within the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts.
Adults: the usual dose of oral doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg daily.For children above 8 years of age: The recommended dosage schedule for children weighing 45 kg or less is 4.4 mg/kg of body weight divided into two doses on the first day of treatment, followed by 2.2 mg/kg of body weight given as a single daily dose or divided into two doses on subsequent days.s. For more severe infections up to 4.4 mg/kg of body weight may be used. For children over 45 kg, the usual adult dose is used.
Contraindicated in persons who have shown hypersensitivity to any of the ingredients in the product, other tetracyclines.
The use of drugs of the tetracycline-class during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). Clostridium difficile-associated diarrhea. Patients should be evaluated if diarrhea occurs. Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines.
Pregnancy category D. Not recommended during pregnancy and lactation. Doxycycline use should be avoided during nursing. Should not be used in paediatrics under 8 years, because of the effects of drugs of the tetracycline-class on tooth development and growth.
Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron-containing preparations. Concurrent use of tetracycline may render oral contraceptives less effective. Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Most common adverse reactions are anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, and hemolytic anemia.
Doctors
Nurses
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