Microcef CV (Cefpodoxime +Potassium clavulanate)

• Composition :
  Each tablet contains Cefpodoximeproxetil 100mg DT/200mg+ Potassium Clavulanate 62.5/125 mg Tablets
• Indications :
  For LowerRespiratory Tract Infections, Upper Respiratory Tract Infections and Urinary Tract Infections.
• Pharmacodynamics :
  Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.Clavulanic acid is a beta-lactam structurally related to penicillins. It inactivates beta-lactamase enzymes.
• Dosage and administration :
  Adults:Pharyngitis and/or tonsillitis- 100 mg every 12 hoursfor 5–10 days,Uncomplicated urinary tract infection-100 mg every 12 hours for 7 days.In children:2months to 12 years: 4-5 mg/kg every 12 hours (Max 200 mg/dose) for 5 – 10 days. Dosage beased on cefpodoxime component.
• Contraindications :
  CefpodoximeProxetil is contraindicated in patients with known hypersensitivity to Cefpodoxime or to the cephalosporin group of antibiotics.
• Precautions and warnings :
  Clostridium difficile-associated diarrhea (CDAD) has been reported with the use of nearly all antibacterial agents, including cefpodoximeproxetil, and may range in severity from mild diarrhoea to fatal colitis.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in children below 2 months of age.This product should only be used in pregnancy if considered essential by the physician.Excreted in milk can cause potential for serious reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
• Drug interactions :
  Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduce peak plasma levels of cefpodoxime. Renal excretion of Cefpodoxime was inhibited by probenecid
• Adverse reactions :
  The side effects include diarrhoea, nausea, skin & vaginal fungal infection, abdominal pain, dyspepsia
• Therapy Area :
  Anti-Bacterials