Microcef (Cefpodoxime)

• Composition :
  Each tablet contains CefpodoximeProxetil 50/100/200 mg DT, 50mg/5ml and 100mg/5ml Syrup.
• Indications :
  For Acute bronchitis, exacerbations of chronic bronchitis, bronchiolitis pneumonia, sinusitis, recurrent chronic tonsillitis, pharyngitis, acute otitis.
• Pharmacodynamics :
  Cefpodoxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefpodoxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
• Dosage and administration :
  100mg-200mg twice daily.In children:2months to 12 years: 5 mg/kg Q 12 h.
• Contraindications :
  CefpodoximeProxetil is contraindicated in patients with known hypersensitivity to Cefpodoxime or to the cephalosporin group of antibiotics.
• Precautions and warnings :
  In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of CefpodoximeProxetil should be reduced.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects: Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Should be used in pregnancy only if clearly needed.Avoid use during nursing. Safety and efficacy in pediatric patients less than 2 years is not established.
• Drug interactions :
  Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H2 blockers reduce peak plasma levels of cefpodoxime. Renal excretion of Cefpodoxime was inhibited by probenecid
• Adverse reactions :
  The side effects include headache diarrhoea, abdominal pain and dyspepsia.
• Therapy Area :
  Anti-Bacterials