Gramocef S Injection (Ceftriaxone + Sulbactam)

• Composition :
  Each vial contains Ceftriaxone 1gm+ Sulbactam 500 mg inj.
• Indications :
  For the treatment of urinary tract infections and lower respiratory tract infections, caused by various bacteria.
• Pharmacodynamics :
  Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.
• Dosage and administration :
  The usual adult daily dose is 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. For the treatment of uncomplicated gonococcal infections, a single intramuscular dose of 250 mg is recommended. For preoperative use (surgical prophylaxis), a single dose of 1 gram administered intravenously 1/2 to 2 hours before surgery is recommended.
• Contraindications :
  Hypersensitivity to any of the ingredients/components of the product. And in patients with previous hypersensitivity reactions to penicillin and other beta lactam antibacterial agents may be at greater risk of hypersensitivity to ceftriaxone.
• Precautions and warnings :
  Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution, to reconstitute Ceftriaxone vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. If a patient develops anaemia while on ceftriaxone, the diagnosis of a cephalosporin associated anaemia should be considered and ceftriaxone stopped until the etiology is determined.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in human pregnancy and lactation. This product should only be used in pregnancy if considered essential by the physician. GRAMOCEF-S injection is not intended to be used in children.
• Drug interactions :
  Diclofenac increases biliary excretion of the drug, acyclovir increases renal toxicity, amikacin leads to nephrotoxicity, cliclosporin levels increases- when administered concomitantly with ceftriaxone.
• Adverse reactions :
  The most frequent side effects were diarrhoea, pain at site of injection, rash, inflammation of a vein caused by blood clots, itching of skin, nausea.
• Therapy Area :
  Anti-Bacterials