Gramocef O 400 (Cefixime)

• Composition :
  Each tablet contains Cefixime400mg.
• Indications :
  Indicated in the treatment of UTI, RTI and Typhoid fever.
• Pharmacodynamics :
  Cefixime is a semi-synthetic, oral third-generation cephalosporin, which has marked in vitro bactericidal activity against a wide variety of gram-positive and gram-negative organisms. Bactericidal action of cefixime results from inhibition of cell-wall synthesis.
• Dosage and administration :
  Adults: 400 mg daily
• Contraindications :
  Cefixime is contraindicated in patients with a known allergy to cefixime or other cephalosporins or any of the other components of the product.
• Precautions and warnings :
  Hypersensitivity reactions including shock and fatalities have been reported with cefixime. Discontinue use if a reaction occurs. Clostridium difficile associated diarrhea: Evaluate if diarrhea occurs.Cefixime may be associated with a fall in prothrombin activity
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in human pregnancy and lactation. Cefixime should, therefore, not be used in pregnancy or in nursing mothers unless considered essential by the physician.
• Drug interactions :
  Elevated carbamazepine levels have been reported in post-marketing experience when cefixime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.
• Adverse reactions :
  Most common adverse reactions are gastrointestinal such as diarrhea, nausea, abdominal pain, dyspepsia,dizziness, vomiting.
• Therapy Area :
  Anti-Bacterials