Each tablet contains Cefixime 200mg + Clavulanic Acid 125 mg.
For the treatment of Upper Respiratory Tract Infections (URTIs), otitis media, pharyngitis and tonsillitis, acute exacerbations of chronic bronchitis, UTI, biliary tract infections and dental infections.
Cefixime is a semi-synthetic, oral third-generation cephalosporin, which has marked in vitro bactericidal activity against a wide variety of gram-positive and gram-negative organisms. Bactericidal action of cefixime results from inhibition of cell-wall synthesis. Clavulanic acid is an irreversible inhibitor of intracellular and extracellular beta-lactamases.
Adults and Children over 12 Years of Age: One tablet twice daily. The usual course of treatment is 7 days. This may be continued for up to 14 days if required.
Cefixime is contraindicated in patients with a known allergy to cefixime or other cephalosporins or any of the other components of the product.
Anaphylactic/anaphylactoid reactions (including shock and fatalities) have been reported with the use of cefixime. The dose should be adjusted in patients with renal impairment as well as those undergoing continuous ambulatory peritoneal dialysis and hemodialysis.
There are no adequate and well-controlled studies in human pregnancy, lactation and infants. Efficacy and safety in infants aged less than 6 months have not been established.
Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly with warfarin and anticoagulants. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations as elevated carbamazepine levels have been reported.
Most common adverse reactions are gastrointestinal such as diarrhea, nausea, loose stools, abdominal pain, dyspepsia, and vomiting.
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Nurses
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