Gramocef Injection (Ceftriaxone)

• Composition :
  Ceftriaxone 250mg/500mg/1g & 2g IV/IM
• Indications :
  Ceftriaxone 250mg/500mg/1g & 2g IV/IM Indications:Indicated in the treatment of UTI, lower respiratory tract infections, bacteremia, septicaemia, meningitis, abdominal infections and infections caused by pseudomonas species.
• Pharmacodynamics :
  Ceftriaxone is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
• Dosage and administration :
  Usual adult dose is 1-2g once a day or in divided doses. Should not exceed 4 g/day. For the treatment of uncomplicated gonococcal infections, a single intramuscular dose of 250 mg is recommended. For preoperative use (surgical prophylaxis), a single dose of 1 gram administered intravenously 1/2 to 2 hours before surgery is recommended.
• Contraindications :
  Contraindicated in patients with known allergy to the cephalosporin class of antibiotics.Contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone calcium
• Precautions and warnings :
  As with all beta-lactam antibacterial agents, serious and occasionally fatal hypersensitivity reactions (i.e., anaphylaxis) have been reported. Interaction with calcium-containing Products. Clostridium difficile-associated diarrhea: May range from mild diarrhea to fatal colitis. Evaluate if diarrhea occurs.Hemolytic Anemia: Severe cases of hemolytic anemia, including fatalities, have been reported. If anemia is diagnosed, discontinue the drug until the etiology is determined.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy Catergory B. Low concentrations of ceftriaxone are excreted in human milk. Caution should be exercised when ceftriaxone is administered to a nursing woman. hyperbilirubinemic neonates, especially prematures, should not be treated with Ceftriaxone.
• Drug interactions :
  Concurrent use of ceftriaxone and the calcium salts may result in formation of ceftriaxone-calcium precipitates. Concurrent use of ceftriaxone and cyclosporine may result in an increased risk of cyclosporine toxicity.Vancomycin, amsacrine, aminoglycosides, and fluconazole are physically incompatible with ceftriaxone in admixtures.
• Adverse reactions :
  The most common adverse reactions of ceftriaxone include diarrhea, eosinophilia, thrombocytosis, leukopenia, elevations of SGOT, SGPT, BUN, headache or dizziness.
• Therapy Area :
  Anti-Bacterials