Clariwin Syrup (Clarithromycin)

• Composition :
  Clarithromycin 125mg/5ml Dry Syrup
• Indications :
  Treatment of mild to moderately severe infections like acute exacerbation of chronic bronchitis community acquired pneumonia including infections due to chlamydia, mycoplasma spegiocella acute streptococcal pharyngitis and skin and soft tissue infections
• Pharmacodynamics :
  Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunit of susceptible bacteria resulting in inhibition of protein synthesis
• Dosage and administration :
  Pediatric patients: The recommended daily dosage is given in table below: Weight (kg)* Approximate age in years Dose in mg of clarithromycin to be given twice daily Dose in ml 8 - 11 1 - 2 62.5 2.5 12 - 19 3 - 6 125 5.0 20 - 29 7 - 9 187.5 7.5 30 - 40 10 - 12 250 10.0
• Contraindications :
  Clarithromycin is contraindicated in patients with a known hypersensitivity to clarithromycin, erythromycin, or any of the macrolide antibiotics.Clarithromycin should not be given to patients with hypokalaemia
• Precautions and warnings :
  Clarithromycin has been associated with prolongation of the QT interval and infrequent cases of arrhythmia. Clarithromycin should be avoided in patients with ongoing pro-arrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia
• Drug interactions :
  Co-administration of Clariwin syrup can alter the concentrations of other drugs. The potential for drug-drug interactions must be considered prior to and during therapy.Concomitant administration of Clariwin syrup with cisapride and pimozide is contraindicated due to risk of cardiac arrhythmias
• Adverse reactions :
  The most frequently reported events in adults taking Clariwin tablets (clarithromycin tablets) arediarrhoea, nausea, abnormal taste, dyspepsia, abdominal pain/discomfort, and headache
• Therapy Area :
  Anti-Bacterials