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Limbival and Limbival Forte Tablets (Amitriptyline + Chlordiazepoxide Tablets _ Amitriptyline + Chlordiazepoxide)

  • Each Limbival tablet contains Amitriptyline 12.5mg + Chlordiazepoxide 5 mg and Limbival Forte contains Amitriptyline 25mg + Chlordiazepoxide 10 mg
  • Indicated for the treatment of depression associated with anxiety
  • Amitriptyline is a tricyclic antidepressant, interferes with the reuptake of norepinephrine into adrenergic nerve endings, this action may prolong the sympathetic activity of biogenic amines. Chlordiazepoxide is a benzodiazepine (BZD) has been shown to act on the limbic system. Evidence indicates that the limbic system is involved in an emotional response.
  • Tablets are recommended in an initial dosage of 3 or 4 tablets daily in divided doses; this may be increased to 6 tablets daily as required.
  • Thoughts of suicide and worsening of depression may increase when starting antidepressants. Patients with manic-depressive illness may enter into a manic phase alcohol is not advised as it might increase the sedative effect.
  • Safety and efficacy have not been established in pregnancy and lactation, Limited human data suggest that the drug could represent a significant risk to the newborn.
  • Because of its amitriptyline component, Limbival and Limbival Forte may block the antihypertensive action of guanethidine or compounds with a similar mechanism of action.
  • The most common adverse reactions are drowsiness, dizziness, dry mouth, constipation and bloating.
  • Anti-Depressants