Bipacef Injection ( Cefuroxime)

• Composition :
  Each vial contains Cefuroxime Sodium 750/1500 mg (as sterile powder for reconstitution)
• Indications :
  Indicated in the treatment of respiratory tract infections, UTI, ENT soft tissue infections etc
• Pharmacodynamics :
  Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor
• Dosage and administration :
  Adults: The usual adult dosage range for Bipacef is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. For IV and IM Use: Each 750 mg vial should be constituted with 3.0 mL/8ml of Sterile Water for Injection. Shake gently to disperse and withdraw completely the resulting suspension for injection
• Contraindications :
  In patients with a known allergy to the cephalosporin group of antibiotics
• Precautions and warnings :
  This product should be given cautiously to penicillin-sensitive patients. Antibiotics should be administered with caution to any patient who has demonstrated some form of allergy, particularly to drugs. If an allergic reaction to cefuroxime occurs, discontinue the drug. Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken. Broad-spectrum antibiotics should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.Associated with a fall in prothrombin activity. Prothrombin time should be monitored in patients at risk and exogenous Vitamin K administered as indicated
• Use in pregnancy, lactation & pediatrics :
  Pregnancy Category B (no adequate and well-controlled studies in pregnant women). Cefuroxime is excreted in human milk. Caution should be exercised when administered to a nursing woman.Safety and effectiveness in paediatric patients below 3 months of age have not been established
• Drug interactions :
  Cefuroxime affects the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined estrogen/progesterone oral contraceptives
• Adverse reactions :
  The most common adverse reactions include thrombophlebitis,vomiting, abdominal pain, colitis, toxic nephropathy, and hepatic dysfunction, including cholestasis, aplastic anemia, hemolyticanemia, and hemorrhage
• Therapy Area :
  Anti-Bacterials