Channel SR Capsules (Diltiazem Hydrochloride)

• Composition :
  Diltiazem Hydrochloride 90mg / 120mg Sustained Release Capsules.
• Indications :
  Hypertension and improving exercise tolerance in patients with chronic stable angina.
• Pharmacodynamics :
  Diltiazem is calcium channel antagonists, inhibits the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. Decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect.
• Dosage and administration :
  Capsules should be swallowed whole and not chewed or crushed. Initial adult dose is 90mg one tablet daily once, can be increased to 120mg. Adjust dose according to blood pressure response.
• Contraindications :
  Contraindicated in patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker, second-or third-degree AV block except in the presence of a functioning ventricular pacemaker, hypersensitivity, hypotension (<90 mm Hg), acute myocardial infarction and pulmonary congestion.
• Precautions and warnings :
  Bradycardia or AV block, heart failure and acute hepatic injury.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy category C, use only if potential benefit outweighs the potential risk to the fetus. Diltiazem is excreted in human milk. Safety and effectiveness in pediatric patients has not been established.
• Drug interactions :
  Beta blockers, digitalis, and other agents known to impair conduction, bradycardia and heart failure when used with Diltiazem.CYP450 3A4: Diltiazem is both a substrate and inhibitor of CYP450 3A4, substrates require dosage adjustment.
• Adverse reactions :
  The most common adverse reaction are lower limb edema, sinus congestion and rash in patients treated for hypertension and lower limb edema dizziness, bradycardia, first-degree AV block in patients treated for angina.
• Therapy Area :
  Anti-Anginals