Azilide XL Suspension (Azithromycin)

• Composition :
  Each 5 ml syrup contains: Azithromycin 100/200mg
• Indications :
  For susceptible infections including community acquired pneumonia pelvic inflammatory disease
• Pharmacodynamics :
  Themode of action of azithromycin is inhibition of protein synthesis in bacteria by binding to the 50s ribosomal subunit and preventing translocation of peptides
• Dosage and administration :
  The total dosage in children aged 6 months and older is 30 mg/kg administered as 10 mg/kg once daily for three days, or over a period of five days starting with a single dose of 10 mg/kg on the first day, followed by doses of 5 mg/kg per day for the following 4 days
• Contraindications :
  The use of this product is contraindicated in patients with hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic. Contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of azithromycin
• Precautions and warnings :
  Since liver is the principal route of elimination for azithromycin, the use of azithromycin should be undertaken with caution in patients with significant hepatic disease
• Drug interactions :
  Co-administration of nelfinavir at steady-state with a single oral dose of azithromycin resulted in increased azithromycin serum concentrations.Co-administration with efavirenz, or fluconazole had a modest effect on the pharmacokinetics of azithromycin
• Adverse reactions :
  most common treatment-related side effects arediarrhea, abdominal pain, vomiting, nausea and rash
• Therapy Area :
  Anti-Bacterials