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Neurica M Capsules (Pregabalin + Methylcobalamin )

  • Each Capsules contains Pregabalin 75 mg + Methylcobalamin 750 mcg
  • For the treatment of adult patients with peripheral neuropathy
  • Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive effects. Methylcobalamin is a Neurotropic and acts as a growth promoter for nerve cells, acts as a methyl donor for the synthesis of Lecithin, a major component of the Myelin sheath. Facilitates methylation of t-RNA which plays a fundamental role in protein synthesis and stimulates methionine synthesis and helps to restore normal levels of RNA in nerve cells;
  • dose of two capsules b.i.d. Based on individual patient response and tolerability, the dosage may be increased to 4 capsules in two divided doses after an interval of 3 to 7 days.
  • Neurica M is contraindicated in patients with known hypersensitivity to any of the active constituents.
  • Caution should be exercised when prescribing pregabalin to patients who have had a previous episode of angioedema, Antiepileptic drugs (AEDs), including pregabalin, increase the risk of suicidal thoughts or behavior in patients.
  • pregnancy category C: There are no adequate and well-controlled studies in pregnant women. Pregabalin should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The safety and efficacy of pregabalin in pediatric patients have not been established.
  • there are no pharmacokinetic interactions between pregabalin and the following antiepileptic drugs: carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, and topiramate
  • dizziness, somnolence, dry mouth, edema, blurred vision, weight gain
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