PRODUCT DETAILS VIEW ALL PRODUCTS

Pregator SR Tablets (Pregabalin + Methylcobalamin)

  • Each capsule contains Pregabalin 75 mg SR + Metcobalamin 1500mcg
  • For the treatment of painful diabetic neuropathy in adults only.
  • Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. It is a neurotropic and acts as a growth promoter for nerve cells, a property which helps to regenerate central and peripheral nervous tissue damaged in disorder such as diabetic peripheral neuropathy. Methylcobalamin (Mecobalamin, MeCbl), is one of the two biologically active vitamin B12. Mecobalamin acts as an important cofactor in the reaction of one class of the B12 enzymes, the methyltransferases. The B12-dependent methyltransferases play an important role in amino acid metabolism in many organisms as well as in one-carbon metabolism and CO2 fixation in anaerobic microbes.
  • 1 tablet per day with or without food or as directed by the physician.
  • Contraindicated in patients with known hypersensitivity to any other component of this product.
  • Folate should not be routinely used in patients receiving coronary stents. Caution should be exercised when administering folic acid to patients who may have folate dependent tumours. Because of lack of long-term safety data, alpha-lipoic acid should be avoided by pregnant women and nursing mothers. Blood glucose should be monitored and anti-diabetic drug dose adjusted, if necessary, to avoid possible hypoglycemia.
  • There are no adequate and well-controlled studies in human pregnancy, lactation & children.
  • Pregabalin: May potentiate the impairment of motor skills and sedating effects of alcohol. Hence, patients should be advised to avoid alcohol while on therapy with pregabalin. Methylcobalamin: Antibiotic may alter the intestinal microflora and may decrease the absorption of methylcobalamin. Metformin, para-aminosalicylic acid and potassium chloride: May decrease the absorption of methylcobalamin.
  • The most common adverse effects are rashes, headache, abdominal distension, flatulence, anorexia and nausea.
  • Nutraceuticals and Immunoceuticals