Pregator Tablets (Pregabalin + Methylcobalamin + Alpha lipoic acid + Folic acid + Pyridoxine)

• Composition :
  Each capsule contains Pregabalin 75 mg + Methylcobalamin 1500mcg + Folic acid 1.5 mg + Pyridoxine 3 mg + Alpha lipoic acid 200mg Soft Gelatin Capsules.
• Indications :
  For the treatment of painful diabetic neuropathy in adults only.
• Pharmacodynamics :
  Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. It is a neurotropic and acts as a growth promoter for nerve cells, a property which helps to regenerate Central and Peripheral nervous tissue damaged in disorder such as diabetic peripheral neuropathy. Alpha-lipoic acid and its reduced metabolite, dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Pyridoxine hydrochloride is Vitamin B6. It is converted to pyridoxal phosphate which is the co-enzyme for a variety of metabolic transformations. The mucosa of the duodenum and upper part of the jejunum are rich in dihydrofolate reductase, where folates and folic acid are absorbed. Once absorbed, folic acid is rapidly reduced and then methylated to form tetrahydrofolic acid derivatives which are rapidly transported to the tissues.
• Dosage and administration :
  1-2 tablets per day as directed by the physician.
• Contraindications :
  Contraindicated in patients with known hypersensitivity to any other component of this product.
• Precautions and warnings :
  Folate should not be routinely used in patients receiving coronary stents. Caution should be exercised when administering folic acid to patients who may have folate dependent tumours. Because of lack of long-term safety data, alpha-lipoic acid should be avoided by pregnant women and nursing mothers. Blood glucose should be monitored and anti-diabetic drug dose adjusted, if necessary, to avoid possible hypoglycemia.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in human pregnancy, lactation & children. This product should only be used in pregnancy if considered essential by the physician.
• Drug interactions :
  Supplemental alpha-lipoic acid may lower blood glucose levels. Those with diabetes on anti-diabetic medication should have their blood glucose monitored and antidiabetic drug dose appropriately adjusted, if necessary, to avoid possible hypoglycemia. Absorption of folic acid may be reduced by sulfasalazine.
• Adverse reactions :
  The most common adverse effects are rashes, headache, abdominal distension, flatulence, anorexia and nausea.
• Therapy Area :
  Nutraceuticals and Immunoceuticals