Misopt Eye Drops (Dorzolamide Hydrochloride +Timolol Maleate)

• Composition :
  Dorzolamide 2% and Timolol Maleate 0.5% Eye Drops.
• Indications :
  Treatment of elevated intraocular pressure in patients with ocular hypertension on open angle glaucoma.
• Pharmacodynamics :
  Dorzolamide hydrochloride inhibits carbonic anhydrase in the ciliary processes of the eye& decreases aqueous humor secretion, by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a non-selective beta adrenergic receptor blocker that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity.The effect of reducing IOP in eye is thought to be primarily due to reduced aqueous formation.
• Dosage and administration :
  One drop in the affected eye(s) two times daily.
• Contraindications :
  Bronchial asthma, severe chronic obstructive pulmonary disease, Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock. Hypersensitivity to any component of this product
• Precautions and warnings :
  Potentiation of respiratory reactions including asthma,cardiac failure, sulfonamide hypersensitivity,obstructive pulmonary disease, increased reactivity to allergen, potentiation of muscle weakness, masking of hypoglycemic symptoms in patients with diabetes mellitus, masking of thyrotoxicosis.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in pregnant women, nursing woman. Safety and effectiveness in pediatric population have not been established
• Drug interactions :
  Beta-adrenergic blocking agents, Calcium antagonists, Catecholamine-depleting drugs, Digitalis, calcium antagonists, Quinidine, Clonidine antiarrhythmics guanethidine, parasympathomimetics, Cimetidine, hydralazine, phenothiazines and alcohol.
• Adverse reactions :
  Taste perversion (bitter, sour, or unusual taste), burning of eyes, stinging sensation, eye itching. Blurred vision, cataract, conjunctival injection, headache.
• Therapy Area :
  Opthalmologicals