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Acetamide Tablets (Acetazolamide)

  • Acetazolamide 250mg tablets.
  • Indicated for the treatment of chronic simple (open-angle) glaucoma, secondary glaucoma and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure.
  • Acetazolamide is a non-bacteriostatic sulfonamide which inhibits carbonic anhydrase. Carbonic Anhydrase catalyzes the reversible reaction of hydration of carbon dioxide and the dehydration of carbonic acid. In eye, acetazolamide decreases the secretion of aqueous humor resultingdecreased intraocular pressure.
  • 250 mg to 1 g per 1 to 4 times daily, usually in divided doses for amounts over 250 mg.
  • Hypersensitivity to the active substance(s) or to any of the excipients, hyperchloraemic acidosis, hypokalaemia, hyponatraemia, impairment of renal function,marked kidney and liver disease or dysfunction, in suprarenal gland, liver cirrhosis. Contraindicated in patients with chronic non-congestive angle-closure glaucoma.
  • Both increases and decreases in blood glucose levels. Increased muscular weakness. Careful usage in Geriatric patient, diabetes mellitus, impaired alveolar ventilation. The patient should be cautioned to report any unusual skin rash. Severe Cutaneous Adverse Reactions such as Stevens Johnsons Syndrome, Erythema Multiforme, Toxic Epidermal Necrolysis and Acute GeneralisedExanthematousPustulosis may occur with acetazolamide. Hypersensitivity reactions may recur if a sulphonamide or sulphonamide derivative is readministered, irrespective of the route of administration. If signs of hypersensitivity reactions or other serious reactions occur, acetazolamide must be discontinued.
  • There are no adequate and well-controlled studies in pregnant women, nursing woman. Safety and effectiveness in infants below the age of one year have not been established..This product should only be used in pregnancy if considered essential by the physician.
  • Careful co-administration with aspirin, primidone, other carbonic anhydrase inhibitors, folic acid antagonists,methanamine, lithium, sodium bicarbonate, amphetamines,cyclosporine, hypoglycemic agents, phenytoin, quinidine etc.
  • Blood dyscrasias, abnormal liver function, metabolic acidosis, electrolyte imbalance, including hypokalemia, hyponatremia, loss of appetite, taste alteration, hyper/hypoglycemia, allergy, hearing disturbances.
  • Opthalmologicals