Moxigram Eye Drops (Moxifloxacin)

• Composition :
  Moxifloxacin 0.5% eye drops.
• Indications :
  For the treatment of bacterial conjunctivitis caused by susceptible organism.
• Pharmacodynamics :
  The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division
• Dosage and administration :
  One drop in the affected eye 3 times a day for 7 days.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients, to other quinolones.
• Precautions and warnings :
  Hypersensitivity reactions, corneal endothelial cell Injury. As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterialconjunctivitis
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in pregnant women,nursing woman. Safety and effectiveness in infants below the age of one year have not beenestablished.
• Drug interactions :
  Specific drug interaction studies have not been conducted with Gatifloxacin eye drops. However, the systemic administration of some quinolones has been shown toelevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhancethe effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transientelevations in serum creatinine in patients receiving systemic cyclosporine concomitantly
• Adverse reactions :
  Conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, sub-conjunctival hemorrhage, and tearing.
• Therapy Area :
  Opthalmologicals