Extragat Eye Drops (Gatifloxacin)

• Composition :
  Gatifloxacin 0.5% Eye Ointment.
• Indications :
  For the treatment of bacterial conjunctivitis caused by susceptible strains.
• Pharmacodynamics :
  Gatifloxacin is a fluoroquinolone antibacterial drug. The antibacterial action of gatifloxacin results from inhibition of DNA gyrase and topoisomerase IV.DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
• Dosage and administration :
  Patients 1 year of age or older: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times on Day 1. Instill one drop upto four times daily in the affected eye(s) while awake from Day 2 to day 7.
• Contraindications :
  In patients with a history of hypersensitivity to gatifloxacin, to other quinolones, or to any of the components in this formulation.
• Precautions and warnings :
  Hypersensitivity reactions, corneal endothelial cell Injury.As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterialconjunctivitis
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in pregnant women,nursing woman. Safety and effectiveness in infants below the age of one year have not beenestablished.
• Drug interactions :
  Specific drug interaction studies have not been conducted with Gatifloxacin eye drops. However, the systemic administration of some quinolones has been shown toelevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhancethe effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transientelevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.
• Adverse reactions :
  Conjunctival irritation, increased lacrimation, keratitis, papillary conjunctivitis, chemosis, conjunctival hemorrhage, dry eye, discharge, headache, reduced visual acuity and taste disturbance.
• Therapy Area :
  Opthalmologicals