Ebast Suspension (Ebastine)

• Composition :
  Each 5ml suspension contains Ebastine 5mg/5ml.
• Indications :
  Indicated for Seasonal & perennial allergic rhinitis & chronic idiopathic urticaria.
• Pharmacodynamics :
  Ebastine, a piperidine derivative, is a long-acting, non-sedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It has antihistaminic, anti-allergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or anti-muscarinic actions.
• Dosage and administration :
  Children between 2 and 5 years: 2.5 ml once daily, Children between 6 and 11 years: 5 ml once daily, Adults and older children more than 11 years: 10 ml once daily.
• Contraindications :
  Hypersensitivity to ebastine or to any of the other excipients of the product.
• Precautions and warnings :
  Caution should be exercised when ebastine is administered to patients with known prolongation of the QTc interval on the electrocardiogram, hypokalemia hepatic impairment and renal insufficiency.
• Drug interactions :
  Caution should be exercised when using ebastine, with any medicine known to produce an increase in QT interval. Drugs which inhibit CYP3A4 enzyme systems such as azole antifungals (ketoconazole and itraconazole) and macrolide antibiotics (erythromycin) may result in increased plasma concentrations of ebastine.
• Adverse reactions :
  The most common side effects are headache, dry mouth and drowsiness.
• Therapy Area :
  Anti-Allergics