PRODUCT DETAILS VIEW ALL PRODUCTS

Osmitol Syrup (Lactitol Monohydrate)

  • Lactitol Monohydrate Syrup 66.67% w/v
  • For the treatment of constipation
  • Lactitol is a disaccharide derivative consisting of galactose and sorbitol, which is only minimally absorbed and is not hydrolysed by the disaccharidases of the gastrointestinal tract and, thus, reaches the colon unchanged. In the colon, it is broken down into short-chain organic acids, mainly acetic, propionic and butyric acid, by the intestinal flora, in particular by the bacteroides and lactobacilli, thus acidifying the contents of the colon. The effect of this acidification reduces the absorption of ammonia. The transformation of lactitol into low-molecular weight organic acid results in an increase in osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume, which explains the laxative affect.
  • Once daily, in the morning or evening, at mealtimes. The usual recommended adult dose is 15 to 30 ml per day
  • Hypersensitivity to the drug or any other component of the formulation, galactosaemia andintestinal obstruction
  • Absorption of lactate from the colonic metabolism of lactitol can potentially result in acid-base disturbances. Diarrhoea induced by lactitol can be associated with hypokalaemia and hypernatraemia,Blood electrolyte levels should be monitored regularly in elderly or debilitated patients on long-term treatment,Patients who complain of nausea should be advised to take lactitol with meals., Lactitol is not recommended in case of ileostomy or colostomy
  • There are no studies showing efficacy and safety of Lactitol Monohydrate Syrupin pregnant, lactating or Paediatric patients.Should be prescribed only if the potential benefits outweigh the potential risk.
  • Lactitol can increase the potassium losses caused by other medicines (e.g. thiazide diuretics, corticosteroids, carbenoxolone, amphotericin), Lactitol can increase digitalis toxicity, broad-spectrum antibacterial agents and antacids are administered along with lactitol, it can cause a reduction in the acidification effect of lactitol.
  • Lactitol can increase the potassium losses caused by other medicines (e.g. thiazide diuretics, corticosteroids, carbenoxolone, amphotericin), Lactitol can increase digitalis toxicity, broad-spectrum antibacterial agents and antacids are administered along with lactitol, it can cause a reduction in the acidification effect of lactitol.
  • Osmotic derivatives