Torsinex tablets (Torsemide)

• Composition :
  Each tablet contains Torsemide 10/20/100mg.
• Indications :
  Indicated in treatment of hypertension and edema associated with congestive heart failure
• Pharmacodynamics :
  Torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, inhibits the Na+/K+/2Cl–-carrier system, increases the urinary excretion of sodium, chloride, and water.
• Dosage and administration :
  For edema associated with heart failure initial dose is 10 mg or 20 mg once daily. For hypertension- the recommended initial dose is 5 mg once daily. After 4-6 weeks, increase to 10 mg once daily, if needed.
• Contraindications :
  Hypersensitivity to Torsemide or to povidone and in patients with anuria, and hepatic coma.
• Precautions and warnings :
  Hypotension and worsening renal function, electrolyte and metabolic abnormalities & ototoxicity, hepatic disease with cirrhosis and ascites.
• Use in pregnancy, lactation & pediatrics :
  There are no available data on use of torsemide in pregnant and lactating women. Safety and effectiveness in pediatric patients have not been established.
• Drug interactions :
  Monitor lithium level, caution should be excised when are co-administered with indomethacin. Concomitant use of torsemide with aminoglycoside, ACE inhibitors, corticosteroids and ACTH is not recommended. Non-steroidal anti-inflammatory drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects; risk of renal impairment
• Adverse reactions :
  Excessive urination, metabolic alkalosis, fluid and electrolyte imbalance. (e.g. hypovolemia, hyponatremia).
• Therapy Area :
  Diuretics