PRODUCT DETAILS VIEW ALL PRODUCTS

Torsinex Plus Tablets ( Torsemide +Spironolactone )

  • Each tablet contains Torsemide 10mg + Spironolactone 25mg.
  • Indicated for the treatment of edema associated with congestive heart failure and liver cirrhosis and hypokalemia.
  • Torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, inhibits the Na+/K+/2Cl–-carrier system, increases the urinary excretion of sodium, chloride, and water. Spironolactone is an aldosterone antagonist, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained.
  • One tablet once daily.
  • Torsemide is contraindicated in patients with known hypersensitivity to Torsemide or to povidone and in anuria, and hepatic coma. Spironolactone- is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.
  • Torsemide -Hypotension and worsening renal function, electrolyte and metabolic abnormalities & ototoxicity. Spironolactone- Potassium supplementation, severe heart failure and fluid or electrolyte imbalance
  • It is contraindicated in pregnancy. Spironolactone metabolite appears in human breast milk so caution should be exercised. Safety and effectiveness in pediatric patients have not been established.
  • Torsemide-Monitoring of lithium level is needed, NSAID & CYP2C9 inhibitor should be used with caution when co-administered with torsemide. Concomitant use of torsemide with aminoglycoside, ACE inhibitors, corticosteroids and ACTH is not recommended.
  • The most common adverse reaction with Torsemide is excessive urination, dizziness, and hyperglycemia. Spironolactone- Gynecomastia, Gastric bleeding, ulceration, gastritis, diarrhea, nausea, vomiting, hypersensitivity, hyperkalemia, headache, drowsiness and lethargy.
  • Diuretics