For the acute treatment of inflammatory musculoskeletal disorders associated with painful muscle spasm in adults.
Etoricoxib selectively inhibits cyclooxygenase enzyme (COX-2). This reduces prostaglandins (PGs) generation from arachidonic acid.
Thiocholchicoside is a muscle relaxing agent that works through selective binding to the GABA-A receptor. It prevents muscle contractions by activating the GABA inhibitory motor pathway.
One tablet once a day orally.
Hypersensitivity to the active substance(s) or to any of the excipients.. Patients with active peptic ulceration or active gastro-intestinal (GI) bleeding.
: Caution is advised with treatment of patients most at risk of developing a gastrointestinal complication with NSAIDs; the elderly, patients using any other NSAID or acetylsalicylic acid concomitantly or patients with a prior history of gastrointestinal disease, such as ulceration and GI bleeding. Selective COX-2 inhibitor class of drugs may be associated with a risk of thrombotic events (especially myocardial infarction (MI) and stroke).
Etoricoxib is contraindicated in pregnancy. Women who use etoricoxib must not breast feed. Etoricoxib is contra-indicated in children and adolescents under 16 years of age
Concurrent use of etoricoxib and warfarin may result in increased prothrombin time, International Normalized Ratio (INR). Concurrent use of etoricoxib and rifampicin may result in decreased plasma concentration of etoricoxib.
The most common adverse effects are abdominal pain, Constipation, flatulence, gastritis, heartburn/acid reflux, diarrhea, dyspepsia/epigastric discomfort, nausea, vomiting, oesophagitis, oral ulcer.