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Dolowin Tablets (Aceclofenac)

  • Each tablet contains Aceclofenac 100mg.
  • For the treatment of pain & inflammation in patients with osteoporosis, rheumatoid arthritis and ankylosing spondylitis.
  • Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.
  • The recommended dose is 200 mg daily, taken as two separate 100 mg doses, one tablet in the morning and one in the evening.
  • Hypersensitivity to Aceclofenac or to any of the excipients, active or history of recurrent peptic ulcer/haemorrhage, hepatic failure and renal failure, patients with established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease, history of gastrointestinal bleeding or perforation, related to previous NSAIDS therapy and active bleedings or bleeding disorders.
  • Caution should be exercised, while administering aceclofenac tablets to patients with respiratory disorders, cardiovascular, renal or hepatic impairment, gastrointestinal bleeding, ulceration and perforation. NSAIDs have the potential of causing fatal dermatological reactions including exofoliative dermatitis and hypersensitivity reactions including anaphylactoid reactions. Hence, Aceclofenac should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
  • Aceclofenac should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the foetus.
  • Anti-hypertensives: NSAIDs, may reduce the effect of activity anti-hypertensives. Diuretics: Aceclofenac, like other NSAIDs, may inhibit the activity of diuretics.Cardiac glycosides like digoxin: NSAIDs may exacerbate cardiac failure, reduce GFR (glomerular filtration rate) and inhibit the renal clearance of glycosides, resulting in increased plasma glycoside levels. Hence, the combination should be avoided unless beneficial. Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding. Anti-coagulants: NSAIDs may enhance the effects of anti-coagulants, such as warfarin. Close monitoring of patients on combined anti-coagulants and aceclofenac tablets therapy should be undertaken.
  • Dizziness, dyspepsia, abdominal pain, nausea, diarrhoea and elevated hepatic enzymes.
  • Anti-Inflammatories