Dolowin Spas Tablets (Aceclofenac + Drotaverine)

• Composition :
  Each tablet contains Aceclofenac 100mg + Drotaverine 80mg.
• Indications :
  Indicated for the treatment of adult patients with muscular pain associated with spasm.
• Pharmacodynamics :
  Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins. Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
• Dosage and administration :
  Two tablets daily, taken as one tablet in the morning and one in the evening.
• Contraindications :
  Contraindicated in patients with a history of or active, recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding) and in patients with known sensitivity to this drug or other any other ingredients.
• Precautions and warnings :
  Caution is required if DOLOWIN SPAS is administered to patients suffering from, or with a previous history of, bronchial asthma as NSAIDs have been reported to precipitate Bronchospasm in such patients. NSAIDs should be given with care to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as these conditions may be exacerbated.
• Use in pregnancy, lactation & pediatrics :
  Not recommended in pregnant woman as there is no information during pregnancy. The drug is not recommended in lactating women. Not recommended in children under 18 years of age.
• Drug interactions :
  Diuretics can increase the risk of nephrotoxicity of NSAIDs. Although it was not shown to affect blood pressure control when co-administered with bendrofluazide, interactions with other diuretics cannot be ruled out.NSAIDs may exacerbate cardiac failure, reduce GFR (glomerular filtration rate) and increase plasma glycoside levels.
• Adverse reactions :
  The most frequent side effects arediarrhoea, nausea, vomiting, stomach pain, loss of appetite, dryness in mouth, dizziness, feeling thirsty, heartburn.
• Therapy Area :
  Anti-Inflammatories