Dolowin Forte Tablets (Aceclofenac + Paracetamol + Serratiopeptidase)

• Composition :
  Each tablet contains Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15mg
• Indications :
  Relieve pain and swelling in various conditions like muscle pain, joint pain, soft tissue injury and postoperative pain.
• Pharmacodynamics :
  Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme, COX, which is involved in the production of prostaglandins. Paracetamol is an aniline derivative with analgesic and antipyretic actions similar to those of aspirin, but with no demonstrable anti-inflammatory activity. Serratiopeptidase binds to alpha-2-macroglobulin in the blood in the ratio of 1:1, which helps to mask its antigenicity, but retain its enzymatic activity. Levels of serratiopeptidase are slowly transferred to the exudate at the site of inflammation and gradually, the blood level declines. Serratiopeptidase is a potential anti-inflammatory agent. It decreases the amount of fluid in the tissues, thins the fluids and facilitates the drainage of fluid, thereby reduces swelling
• Dosage and administration :
  Two tablets daily, taken as one tablet in the morning and one in the evening.
• Contraindications :
  Contraindicated in patients with a history of or active, recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding) and in patients with known sensitivity to this drug or other any other ingredients
• Precautions and warnings :
  Caution is required if administered to patients suffering from, or with a previous history of, bronchial asthma since NSAIDs have been reported to precipitate bronchospasm in such patients. Paracetamol may cause liver damage if more than the recommended dose is taken. Allergic reactions like swelling of the face, mouth and throat, difficulty in breathing, itching or rash may occur due to high doses of paracetamol.
• Use in pregnancy, lactation & pediatrics :
  Not recommended in pregnant woman as there is no information during pregnancy. The drug is not recommended in lactating women. Not recommended in children under 18 years of age.
• Drug interactions :
  Avoid concomitant use of two or more NSAIDs (including aspirin) as this may increase the risk of adverse effects. NSAIDs may exacerbate cardiac failure, reduce the glomerular filtration rate (GFR) and increase plasma glycoside levels.
• Adverse reactions :
  The most frequent side effects are nausea, vomiting, Stomach pain, indigestion, heartburn, loss of appetite, diarrhoea
• Therapy Area :
  Anti-Inflammatories