Divon S (Diclofenac + Serratiopeptidase)

• Composition :
  Each tablet contains Diclofenac Potassium 50 mg and Serratiopeptidase 10mg.
• Indications :
  For the treatment of acute pain in adults.
• Pharmacodynamics :
  Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. The mechanism of action is related to inhibition of the cyclooxygenase (COX-1 and COX-2) pathways thatplays a major role in causing inflammation, pain and fever. Serratiopeptidase has anti-inflammatory properties and is particularly useful for post-traumatic swelling.
• Dosage and administration :
  1-2 tablets per day orally.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients.Divon-S tablets should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients. Diclofenac is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
• Precautions and warnings :
  Caution should be exercised in patients with: known CV disease or risk factors for CV disease, prior history of ulcer disease or GI bleeding, fluid retention and edema, impaired renal and hepatic impairment and those taking diuretics or ACE inhibitors. Discontinue the drug if anaphylactic reactions occur. New onset or worsening hypertension may occur which warrants regular blood pressure monitoring.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in pregnant women. Hence, not recommended during pregnancy.It is not known whether this drug is excreted in human milk.Avoid use during lactation.Safety and effectiveness in pediatric patients have not been established.
• Drug interactions :
  Concomitant use of diclofenac and aspirin is not generally recommended because of the potential of increased adverse effects including increased GI bleeding.Concomitant use of ACE Inhibitors, angiotensin receptor blockers (ARB), or beta-blockers with diclofenac may diminish the antihypertensive effect of these drugs. The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
• Adverse reactions :
  The most frequently reported adverse experiences occurring in patients are: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal) and vomiting.
• Therapy Area :
  Anti-Inflammatories