L-Trix Cream (Luliconazole)

• Composition :
  Luliconazole 1% Cream
• Indications :
  Luliconazole Cream is indicated for the topical treatment of cutaneous mycosis, i.e tinea pedis, tinea cruris, and tinea corporis.
• Pharmacodynamics :
  Luliconazole inhibits ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.
• Dosage and administration :
  Tinea pedis once daily for 2 weeks. Tinea cruris once daily for 2 weeks.
• Contraindications :
  Hypersensitivity to luliconazole or any of the excipients of the formulation
• Precautions and warnings :
  In patients with hypersensitivity to luliconazole or any of the excipients of the formulation.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy Category C. It should be used during pregnancy only if potential benefit justifies the potential risk to the foetus. Caution should be exercised in nursing mothers. The safety and effectiveness in paediatric patients has not been established.
• Drug interactions :
  The potential of luliconazole to inhibit cytochrome P-450 (CYP) enzymes luliconazole at therapeutic doses, particularly when applied to patients with moderate to severe tinea cruris, may inhibit the activity of CYP2C19 and CYP3A4.
• Adverse reactions :
  Application site reactions.
• Therapy Area :
  Dermatologicals and Cosmetologicals