Zilarta Tablets (Azilsartan )

• Composition :
  Each tablet contains AzilsartanKamedoxomil eq. to AzilsartanMedoxomil 40mg /80mg.
• Indications :
  treatment of hypertension in adult patients, either alone or in combination with other antihypertensive agents.
• Pharmacodynamics :
  Azilsartan selectively antagonises the effects of angiotensin II by blocking its binding to the AT1receptor in multiple tissues.Azilsartan exhibits a greater affinity for the AT1 receptor compared with the AT2 receptor.
• Dosage and administration :
  One tablet a day.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients.Do not co-administer aliskiren-containing products with Azilsartanin patients withdiabetes. Avoid use in Pregnancy
• Precautions and warnings :
  Symptomatic hypotension is possible. Inhibiting the renin-angiotensin system, changes in renal function may be anticipated in susceptible individuals treated with azilsartan. Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects, Pregnancy Categories C (first trimester) and D (second and third trimesters).Discontinue the tablet as soon aspregnancy is detected, There are no adequate and well-controlled studies in nursing women and children.
• Drug interactions :
  The antihypertensive effect of angiotensin II receptor antagonists, including azilsartan, may beattenuated by NSAIDs, including selective COX-2 inhibitors.No clinically significant drug interactions have been observed in studies of azilsartanmedoxomil or azilsartan given with amlodipine, antacids, chlorthalidone, digoxin, fluconazole, glyburide, ketoconazole, metformin, pioglitazone, and warfarin.
• Adverse reactions :
  The most commonly reported adverse events are diarrhoea, asthenia, muscle spasm, dizziness.
• Therapy Area :
  Anti-Hypertensives