Cilnidipine is a dihydropyridine calcium-channel blocker. It inhibits cellular influx of calcium, thus causing vasodilatation. It has greater selectivity forvascular smooth muscle. Olmesartan- Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist. Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. Chlorthalidone is a benzothiadiazide (thiazide)-related diuretic with a long duration of action. It primarily acts on the distal renal tubule, inhibiting NaCl¯ reabsorption.
One tablet once dailyin the morning.
Nulong Trio is contraindicated in patients with aortic stenosis, anuria and in patients with known hypersensitivity to any active ingredients or any other component of this product.
Cilnidipine- Hypotension, poor cardiac reserve, heart failure, chronic renal insufficiency and hepatic dysfunction. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration. Olmesartan- Observe for signs and symptoms of hypotension in volume- or salt-depleted patients with treatment initiation, Monitor for worsening renal function in patients with renal impairment. Chlorthalidone- Should be used in caution in patients with severe renal disease and hepatic impairment. Hypokalemia and other electrolyte abnormalities, including hyponatremia and hypochloremic alkalosis, are common in patients receiving chlorthalidone. These abnormalities are dose-related.Serum electrolytes should be determined before initiating therapy and at periodic intervals during therapy.
Not recommended for use in pregnancy. Avoid use during breastfeeding. Safety and efficacy in pediatric patients is not established.
Cilnidipine can interact with aldesleukin, quinidine, phenytoin, rifampicin, erythromycin, other anti-hypertensive drugs and anti-psychotic drugs. Olmesartan- NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect Chlorthalidone- Chlorthalidone may add to or potentiate the action of other antihypertensive drugsAdjustment the dosage of insulin and oral anti-diabetic agents may be required. Concomitant administration of certain NSAIDs may reduce the diuretic and antihypertensive activity of chlorthalidone.
Headache, dizziness, hypotension, peripheral edema, flushing rash, gingival hyperplasia, palpitations, GI disturbances and electrolyte abnormalities.
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