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Nebilong AM Tablets (Nebivolol + Amlodipine)

  • Each tablet contains Nebivolol 5mg + Amlodipine 5mg.
  • It is used as an anti-hypertensive agent.
  • Nebivolol is a β-adrenergic receptor blocking agent. The mechanism of action of the antihypertensive response of Nebivolol has not been definitively established. Possible factors that may be involved include: decreased heart rate, decreased myocardial contractility, diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, suppression of renin activity and vasodilation and decreased peripheral vascular resistance. Amlodipine binds to both dihydropyridine and non-hydropyridine binding sites. Itinhibits calcium ion influx. It is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure
  • One tablet once daily.
  • Nebilong AM is contraindicated in hypersensitivity to the active substance or to any of the excipients, severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure and sick sinus syndrome (unless a permanent pacemaker is in place).
  • Nebivolol- Do not abruptly discontinue nebivolol therapy in patients with coronary artery disease. Severe exacerbation of angina, myocardial infarction and ventricular arrhythmias have been reported in patients with coronary artery disease following the abrupt discontinuation of therapy with β-blockers.; Amlodipine-Symptomatic hypotension, worsening angina and acute myocardial infarction, titrate slowlyto patients with severe hepatic impairment.
  • Pregnancy Category C. Should be used in pregnancy only if clearly needed. It is not known whether this drug is excreted in human milk. Hence, not recommended during lactation. Safety andeffectiveness in pediatric patientshave not been established.
  • Nebivolol- Use with caution when co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.). Concomitant use with digitalis glycosides and β-blockers can increase the risk of bradycardia. Reserpine or clonidine may produce excessive reduction of sympathetic activity. Amlodipine- Strong inhibitors of CYP3A4(e.g. ketoconazole, itraconazole, ritonavir) may increase the plasma concentrations of amlodipine to a greater extent.
  • Headache, peripheral edema, fatigue, nausea, abdominal pain, and somnolence.
  • Anti-Hypertensives