Each 10ml syrup contains Ambroxol hydrochloride 30 mg, Terbutaline sulphate IP 2.5 mg and Guaiphenesin 100 mg
For the symptomatic relief of bronchospasm in bronchial asthma & chronic bronchitis.
Terbutaline is a selective beta 2 - adrenergic causing bronchodilation, increase in mucociliary clearance; suppression of oedema and anti-allergic effects. Ambroxol possesses expectorant effect. Guaifenesin is a glyceryl guaiacolate with expectorant effects.
Adults: 10-20 ml thrice daily, Children (6-12 years): 10 ml thrice daily, Children (under 6 years): 5-10 ml thrice daily.
Hypersensitivity to any of the components of the formulation. It should not be used in patients with pre-existing ischaemic heart disease or those patients with significant risk factors for ischaemic heart disease. It is also contraindicated in patients with gastric ulceration.
Should be used in caution in patients with underlying severe heart disease (e.g. ischaemic heart disease, arrhythmia or severe heart failure). Guaiphenesin should be not used for persistent or chronic cough, such as occurs with asthma, or where cough is accompanied by excessive secretions, unless directed by a physician
There are no adequate and well-controlled studies of this combination in pregnant women. It is not known whether this combination is secreted in breast milk.
Terbutaline should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants. Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Terbutaline sulfate, but may produce severe bronchospasm in asthmatic patients.
The most common adverse effects tremor, nervousness, dizziness, headache, drowsiness, heart palpitations, tachycardia, dyspnea and chest discomfort.
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