Metapro XL Tablets (Metoprolol Succinate)

• Composition :
  Each tablet contains Metoprolol Succinate 25/50mgExtended Release Tablets.
• Indications :
  For the treatment of essential hypertension in adults.
• Pharmacodynamics :
  The mechanism of the antihypertensive effects of beta-blocking includes (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity
• Dosage and administration :
  Heart Failure: Recommended starting dose is 25mg in patients with NYHA Class II heart failure, doubled every two weeks to the highest dose tolerated or up to 200 mg, Hypertension: Usual initial dosage is 25 to 100 mg once daily. The dosage may be increased at weekly (or longer) intervals until optimum blood pressure reduction is achieved. Dosages above 400 mg per day have not been studied, Angina Pectoris: Usual initial dosage is 100 mg once daily. Gradually increase the dosage at weekly intervals until optimum clinical response has been obtained or there is an unacceptable bradycardia. Dosages above 400 mg per day have not been studied.
• Contraindications :
  Contraindicated in severe bradycardia, second or third degree heart block, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome and in patients who are hypersensitive to any of the component of this product.
• Precautions and warnings :
  Ischemic heart disease,bronchospastic disease,major surgery, diabetes, hepatic impairment, bronchospastic disease, thyrotoxicosis, anaphylactic reactions and peripheral vascular disease.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy category C, there are no adequate and well-controlled studies in pregnant women.Should be used during pregnancy only if clearly needed. Caution to be exercise while administering nursing mothers.Safety and effectiveness in pediatric patients have not been established.
• Drug interactions :
  Drug interactions: Catecholamine depleting drugs have an additive effect, monitorfor hypotension and bradycardia. CYP2D6 inhibitorsincrease plasma concentration. Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia Withdrawal of clonidine may exacerbate the rebound hypertension.
• Adverse reactions :
  Adverse reactions: Most common adverse reactions: dizziness, shortness of breath, bradycardia, hypotension
• Therapy Area :
  Anti-Hypertensives