Methyl prednisolone is indicated for conditions requiring glucocorticoid activity including collagen disease, allergic disease, hypersensitivity reactions. As per MOHFW it is recommended in severe and critical COVID 19.
Act primarily by binding to and activating intracellular glucocorticoid receptors. Activated glucocorticoid receptors bind to promoter regions of DNA Binding of the steroid receptor complex of DNA results in induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and thus the formation of inflammation mediators such as prostaglandins and leukotrienes.
The initial dosage vary from 4 mg to 48 mg of methylprednisolone per day depending on the specific disease entity being treated. The average total daily dose recommended may be given either as a single dose or in divided doses.
In patients who have systemic fungal infections, hypersensitivity to the active substance or to any of the excipients
In general all steroids can increase susceptibility to infection. Methylprednisolone, can increase blood glucose and worsen pre-existing diabetes.
Methylprednisolone should be used only if the potential benefit outweighs the risk during pregnancy and lactation.
Methylprednisolone may increase the clearance of chronic high dose aspirin. Mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone, Phenobarbital, phenytoin and rifampin may increase the clearance of methylprednisolone, Troleandomycin and ketoconazole may inhibit the metabolism of methylprednisolone, Aspirin in conjunction with methylprednisolone may increase the clearance of chronic high dose aspirin. The effect of methylprednisolone on oral anticoagulants is variable
Methylprednisolone is associated with side effects like infection, fluid retention, Peptic ulcer, On long term administration osteoporosis, glaucoma, high blood pressure.
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