Neurocetam Tablets (Piracetam).

• Composition :
  Each tablet contains 800 mg or 1200 mg of piracetam.
• Indications :
  For the symptomatic treatment of adult patients suffering from myoclonus of cortical origin, irrespective of etiology, and should be used in combination with other anti-myoclonic therapies.
• Pharmacodynamics :
  Piracetam binds physically in a dose-dependent manner to the polar head of phospholipids membrane models, inducing the restoration of the membrane lamellar structure characterized by the formation of mobile drug-phospholipid complexes. Probably improves membrane stability, allowing the membrane and transmembrane proteins to maintain or recover the three-dimensional structure or folding essential to exert their function. Piracetam has neuronal and vascular effects.
• Dosage and administration :
  The daily dosage should begin at 800 mg increasing up to a maximum of 2400 mg per day, divided in two or three doses and may be taken with or without food
• Contraindications :
  Caution is recommended in patients with severe haemorrhage, patients at risk of bleeding, care should be taken in cases of renal insufficiency, avoid abrupt discontinuation, caution should be exercised by patients who are on a controlled sodium diet. For long-term treatment in the elderly, regular evaluation of the creatinine clearance is required to allow dosage adaptation if needed. Abrupt discontinuation of treatment should be avoided as this may induce myoclonic or generalised seizures in some myoclonic patients.
• Precautions and warnings :
  Caution is recommended in patients with severe hemorrhage, patients at risk of bleeding, care should be taken in cases of renal insufficiency. Avoid abrupt discontinuation, consideration by patients on a controlled sodium diet.
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies of piracetam during pregnancy. Piracetam is excreted in human breast milk. Therefore, piracetam should not be used during breastfeeding or breastfeeding should be discontinued, while receiving treatment with piracetam.
• Drug interactions :
  Piracetam may increase prothrombin time in patients who are on warfarin, concomitant administration with thyroid extract may cause confusion, irritability and sleep disorder. Minor inhibitory effects on CYP 2A6 and 3A4/5 can occur.
• Adverse reactions :
  Most common adverse effects are haemorrhagic disorder, anaphylactoid reaction, hypersensitivity, agitation, anxiety, confusion, hallucination, nervousness, hyperkinesia and increased weight.
• Therapy Area :
  Cerebral Activators_Nootropics