Hipril Tablets (Lisinopril)

• Composition :
  Each tablet contains Lisinopril 5 mg.
• Indications :
  Essential hypertension and in patients with congestive heart failure.
• Pharmacodynamics :
  Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion.
• Dosage and administration :
  One tablet once a day.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients.
• Precautions and warnings :
  Symptomatic hypotension is possible. Angioedema, including laryngeal edema may occur, Renal Impairment: Need to monitor renal function and potassium in susceptible patients.
• Use in pregnancy, lactation & pediatrics :
  Category C (first trimester), category D (second and third trimester).Discontinue drug if pregnancy is detected. It is not known whether this drug is excreted in human milk a decision should be made whether to discontinue nursing or Lisinopril, taking into account the importance of the drug to the mother. Safety and effectiveness have not been established in patients < 6 years of age or with glomerular filtration rate < 30 mL/min/1.73m2
• Drug interactions :
  Concomitant administration of Lisinopril and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased blood-glucose-lowering effect with risk of hypoglycemia. Co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including Lisinopril, may result in further deterioration of renal function.
• Adverse reactions :
  The most commonly reported adverse events are headache, dizziness, fatigue, nausea,and somnolence.
• Therapy Area :
  Anti-Hypertensives