Hipril A Tablets (Lisinopril + Amlodipine)

• Composition :
  Each tablet contains Lisinopril 5 mg + Amlodipine 5mg.
• Indications :
  Indications: Mild to moderate hypertension.
• Pharmacodynamics :
  Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion. Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.
• Dosage and administration :
  One tablet a day.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients.
• Precautions and warnings :
  Symptomatic hypotension is possible. Angioedema, including laryngeal edema may occur, Renal Impairment: Need to monitor renal function and potassium in susceptible patients.
• Use in pregnancy, lactation & pediatrics :
  Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.Discontinue the drug as soon as possible when pregnancy is detected.It is not known whether this drug is excreted in human milk a decision should be made whether to discontinue nursing or Lisinopril, taking into account the importance of the drug to the mother. Safety and effectiveness have not been established in patients < 6 years of age.
• Drug interactions :
  Concomitant administration of Lisinopril and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased blood-glucose-lowering effect with risk of hypoglycemia. Amlodipine with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers.Amlodipine with warfarin did not change the warfarin prothrombin response time.
• Adverse reactions :
  The most commonly reported adverse events are headache, dizziness, fatigue, nausea,myalgia, abdominal pain, and somnolence.
• Therapy Area :
  Anti-Hypertensives