Herparex Ointment (Acyclovir)

• Composition :
  Acyclovir 5%
• Indications :
  For the treatment of Herpes simplex virus infections of the skin including initial & recurrence genital herpes, herpes labialis, herpes simplex keratitis.
• Pharmacodynamics :
  Acyclovir is an antiviral drug active against herpes simplex virus. The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. Acyclovir triphosphate stops replication of herpes viral DNA.
• Dosage and administration :
  Acyclovir Ointment should be applied five times daily for 4 days.
• Contraindications :
  Acyclovir ointment is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.
• Precautions and warnings :
  is intended for cutaneous use only and should not be used in the eye or inside the mouth or nose. Should only be applied on the affected external aspects of the lips and face in patients with herpes labialis.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy Category B. There are no adequate and well-controlled studies of acyclovir cream in pregnant women. Acyclovir cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topically applied acyclovir is excreted in breast milk, administer to a nursing mother with caution and only when indicated. The safety profile is similar to that of adults. Safety and effectiveness in pediatric patients less than 12 years of age have not been established
• Drug interactions :
  Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with Acyclovir Cream. Due to minimal systemic absorption of acyclovir cream, systemic drug interactions are unlikely. No interactions resulting from topical or systemic administration of other drugs concomitantly with Acyclovir ointment. Due to minimal systemic absorption of systemic drug interactions are unlikely
• Adverse reactions :
  The most commonly observed adverse reactions is local skin reactions at the application site. Angioedema, anaphylaxis, contact dermatitis, eczema can also occur.
• Therapy Area :
  Dermatologicals and Cosmetologicals