Angizaar- H tablet (Losartan + Hydrochlorothiazide)

• Composition :
  Each tablet contains Losartan 50mg + Hydrochlorothiazide 12.5mg.
• Indications :
  For treatment of mild to moderate hypertension.
• Pharmacodynamics :
  Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Hydrochlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption.
• Dosage and administration :
  One tablet once a day in the morning.
• Contraindications :
  Hypersensitivity to the active substance(s) or to any of the excipients. Avoid use in Pregnancy. Coadministration with aliskiren in patients with diabetes
• Precautions and warnings :
  Hypotension, Renal Impairment: Need to monitor renal function and potassium in susceptible patients. Hydrochlorothiazide can cause hypokalaemia and hyponatremia. Avoid concomitant use of an ACE inhibitor and angiotensin receptorblocker. Myocardial infarction: Acute Myopia and Secondary Angle-Closure Glaucoma.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects, Pregnancy Categories C (first trimester) and D (second and third trimesters).Discontinue the tablet as soon aspregnancy is detected, there are no adequate and well-controlled studies established for safety and efficacy in nursing women and children
• Drug interactions :
  Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, syncope, and hyperkalemia.Hydrochlorothiazide - Co-administration of a non-steroidal anti-inflammatory agent, including a selective COX-2 inhibitor can reduce its antihypertensive effects.
• Adverse reactions :
  The most commonly reported adverse events are headache, fatigue, nausea,myalgia, abdominal pain, somnolence, dizziness, upper respiratory infection, nasal congestion, and back pain
• Therapy Area :
  Anti-Hypertensives