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Amlong MT Tablets (Amlodipine + Metoprolol Succinate XL)

  • Each tablet contains Amlodipine2.5/ 5 mg + Metoprolol Succinate 25/50mg
  • Indicated in treatment of Essential Hypertension and Angina Pectoris in Adults.
  • Amlodipine is a calcium ion influx inhibitor of the dihydropyridine group inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle, leading to reductions in peripheral vascular resistance and in blood pressure. Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptor in the heart. Beta (1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
  • One tablet once a day.
  • In patients with known sensitivity to amlodipine or Metoprolol. Metoprolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure.
  • Amlodipine should be used with caution in patients with heart failure, severe hepatic impairment, Increased Angina and/or Myocardial Infarction, symptomatic hypotension with any other peripheral vasodilator. Metoprolol should be used in caution with Ischemic Heart Disease, Bronchospastic Diseases, Major Surgery, Diabetes and Hypoglycemia, Pheochromocytoma, and Thyrotoxicosis, in hypertensive and angina patients who have congestive heart failure.
  • Pregnancy category C drug. There are no adequate and well-controlled studies in pregnant women, Nursing should be discontinued.Safety and effectiveness in pediatric patients have not been established
  • Caution should be exercised when amlodipine and sildenafil were used in combination. Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A4 inhibitors(e.g., ketoconazole, itraconazole, ritonavir).Amlodipine may increase hypotensive activities of Acebutolol, Aliskiren, Alprenolol, Bimatoprost, Bisoprolol, Brimonidine, Carvedilol, Cilazapril,Vardenafil may increase the antihypertensive activities of Amlodipine. The metabolism of Amlodipine can be decreased when combined with Ziprasidone. Metoprolol with digitaliscan increase the risk of bradycardia,concomitant use withcatecholamine depletor should be closely observed for evidence of hypotension or marked bradycardia, Rebound hypertension.
  • Palpitations, abdominal pain, dizziness, fainting, fatigue, flushing, headache, lightheadedness, Pedal edema, and hypotension
  • Anti-Hypertensives