Monoguard- B Cream (Sertaconazole Nitrate + Beclomethasone )

• Composition :
  Sertaconazole Nitrate 2% + Beclomethasone 0.025%
• Indications :
  tinea infections associated with inflammatory skin conditions.
• Pharmacodynamics :
  Sertaconazole, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. This enzyme converts lanosterol to ergosterol. Ergosterol is a key component of fungal cell membranes and lack of this component leads to fungal cell injury.Beclomethasone dipropionate has anti-inflammatory, antipruritic actions. It acts by the induction of phospholipase-A2 inhibitory proteins, collectively called lipocortins.
• Dosage and administration :
  Clean and dry the affected areas thoroughly before application of Monoguard B cream.Should be applied to the affected skin areas twice daily
• Contraindications :
  In patients with a history of hypersensitivity to either sertaconazole nitrate, beclomethasone dipropionate or any other excipients of the formulation.
• Precautions and warnings :
  Evidence of exacerbation of pre-existing skin atrophy, Diabetes mellitus, Glaucoma or cataracts,Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, with the potential for glucocorticoid insufficiency after withdrawal of treatment.Liver failure as it may cause HPA axis suppression, Cushing's syndrome, hyperglycemia or glycosuria. Active viral illnesses such as chicken pox or measles.Active viral illnesses such as chicken pox or measles as a topical steroid may increase the risk of serious or fatal infection
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies that have been conducted on topically applied sertaconazole nitrate cream, 2%, in pregnant women. Not recommended in breastfeeding. Safety and efficacy of sertaconazole nitrate and beclomethasone cream has not been established in paediatric patients below 12 years of age.
• Drug interactions :
  Potential interactions between sertaconazole nitrate cream, 2%, and other drugs have not been systematically evaluated. There are no reports of drugs interacting with topical beclomethasone dipropionate.
• Adverse reactions :
  Most common adverse reactions are skin atrophy, telangiectasia, folliculitis, hypertrichosis, perioral dermatitis and adrenocortical suppression.
• Therapy Area :
  Anti-Fungals