Mycophen Tablets (Mycophenolate mofetil )

• Composition :
  Each tablet contains Mycophenolate mofetil 500 mg.
• Indications :
  Mycophen is indicated for the prophylaxis of organ rejection in patients receiving allogeneic hepatic transplantation.
• Pharmacodynamics :
  Mycophenolate mofetil is the 2-morpholinoethyl ester of MPA. MPA is a potent, selective, uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase, and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA.
• Dosage and administration :
  A dose of 1 g bid administered intravenously (over NO LESS THAN 2 HOURS) or 1.5 g bid oral (daily dose of 3 g) is recommended for use in adult hepatic transplant patients.
• Contraindications :
  Mycophenolate mofetil 500mg tablets should not be given to patients with hypersensitivity to mycophenolate mofetil, mycophenolic acid or to any of the excipients.
• Precautions and warnings :
  Immunosuppression may lead to increased susceptibility to infection and possible development of lymphoma. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources.
• Use in pregnancy, lactation & pediatrics :
  Pregnancy category D. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Safety and effectiveness in paediatric patients receiving allogeneic cardiac or hepatic transplants have not been established.
• Drug interactions :
  Mycophen may be administered to patients who are also taking antacids containing magnesium and aluminum hydroxides; however, it is recommended that Mycophen and the antacid not be administered simultaneously. It is recommended that sevelamer and other calcium free phosphate binders preferentially 20 could be given 2 hours after Mycophen intake to minimize the impact on the absorption of MPA.
• Adverse reactions :
  Sepsis, gastrointestinal candidiasis, urinary tract infection, herpes simplex, herpes zoster.
• Therapy Area :
  Immunosuppresants