Norgest Tablets (Norethisterone )

• Composition :
  Each tablet contains Norethisterone 5mg.
• Indications :
  Indicated for Dysfunctional uterine bleeding, polymenorrhoea, menorrhagia, dysmenorrhoea.
• Pharmacodynamics :
  Norethisterone given at intermediate doses (5-10mg) suppresses ovulation via its effect on the pituitary. The endogenous production of oestrogens and progesterones are also suppressed, and the ectopic endometrium is converted to a decidua resembling that of pregnancy. In carcinoma norethisterone may act by pituitary inhibition or by direct action on tumour deposits.
• Dosage and administration :
  1 tablet three times daily for 10 days; bleeding usually stops within 48 hours. Withdrawal bleeding resembling true menstruation occurs a few days after the end of treatment. One tablet twice daily, from days 19 to 26 of the two subsequent cycles, should be given to prevent recurrence of the condition.
• Contraindications :
  Contraindicated in patients with hypersensitivity to any ingredient of the formulation.
• Precautions and warnings :
  therapy should be discontinued in Jaundice or deterioration in liver function,Significant increase in blood pressure, New onset of migraine-type headache
• Use in pregnancy, lactation & pediatrics :
  contraindicated in pregnancy
• Drug interactions :
  The metabolism of progestogens may be increased by concomitant administration of compounds known to induce drug-metabolising enzymes, specifically cytochrome P450 enzymes. Ritonavir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones.
• Adverse reactions :
  breakthrough bleeding, spotting, amenorrhoea, abnormal uterine bleeding, nausea, vomiting, diarrhoea, dry mouth, disturbed liver function, acne, hypersensitivity reactions (e.g., anaphylaxis & anaphylactoid reactions, angioedema).
• Therapy Area :
  Hormones & Hormone Analouges