Biofer S IV lnjection (Iron Sucrose)

• Composition :
  Elemental Iron Sucrose IV Injection 100 mg/ 5 ml
• Indications :
  In iron deficiency anemia in which rapid and reliable substitution of iron is required.
• Pharmacodynamics :
  Biofer-S is an aqueous complex of poly-nuclear iron (III)-hydroxide in sucrose. Following intravenous administration, it dissociates into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron in the precursor cells is incorporated into haemoglobin as the cells mature into red blood cells.
• Dosage and administration :
  Drug must only be administered intravenously either by slow injection or by infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes.
• Contraindications :
  In patients with known hypersensitivity to Iron Sucrose or any other excipients of the formulation. Also contraindicated in patients with evidence of iron overload.
• Precautions and warnings :
  Observe for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes. Elemental Iron Sucrose may cause hypotension, monitor for signs and symptoms following each administration. Regularly monitor hematologic responses during elemental iron sucrose therapy
• Use in pregnancy, lactation & pediatrics :
  Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if clearly needed. It is not known whether iron sucrose is excreted in human milk. Caution should be exercised when administered to a nursing woman. Safety and effectiveness in paediatric patients have not been established.
• Drug interactions :
  Elemental Iron Sucrose should not be administered concomitantly with oral iron preparations since the absorption of oral iron is reduced. Therefore, oral iron therapy should be started at least 5 days after the last injection.
• Adverse reactions :
  Dysgeusia, diarrhoea, nausea, vomiting, headache, dizziness, hypotension, hypertension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain, and peripheral edema, hypersensitivity.
• Therapy Area :
  Haematinics