Petril Beta Tablets (Clonazepam+ Propranolol Hydrochloride )

• Composition :
  Each Petril Beta tablet contains Clonazepam 0.25 mg + Propranolol Hydrochloride 10/20 mg Tablets
• Indications :
  Indicated for treatment of anxiety disorder.
• Pharmacodynamics :
  Clonazepam enhances the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Propranolol is a nonselective, beta-adrenergic receptor-blocker that blocks the action of catecholamines (adrenaline and noradrenaline) at both beta-1 and beta-2 adrenergic receptors, this reduces heart rate, blood pressure.
• Dosage and administration :
  One tablet, once daily taken on empty stomach.
• Contraindications :
  Petril Beta is contraindicated in patients with hypersensitivity to Clonazepam and Propranolol Hydrochloride. Clonazepam should not be used in patients with a history of hypersensitivity to benzodiazepines, patients with significant liver disease and acute narrow angle glaucoma. Propranolol Hydrochloride is contraindicated in Bronchial asthma, Cardiogenic shock and decompensated heart failure.
• Precautions and warnings :
  Clonazepam-Interference with cognitive and motor performance, increased risk of suicidal thoughts or behavior. Propranolol Hydrochloride may worsen congestive heart failure
• Use in pregnancy, lactation & pediatrics :
  There are no adequate and well-controlled studies in pregnant women. Excreted in human milk. Caution should be exercised when administered to a nursing woman and Safety and effectiveness in pediatric patients not been established.
• Drug interactions :
  phenytoin, carbamazepine or phenobarbital alters the pharmacokinetics of clonazepam. Caution should be exercised when patients receiving a beta blocker are administered a calcium channel-blocking drug.
• Adverse reactions :
  Drowsiness, ataxia headache, slurred speech, tremor, vertigo
• Therapy Area :
  Anxiolytics