Beta Anxit Tablets (Alprazolam + Propranolol)

• Composition :
  Alprazolam 0.25 mg + Propranolol 20 mg Tablets.
• Indications :
  In Generalized Anxiety Disorder, Panic Disorder, Post-Traumatic Stress Disorder and Migraine Prophylaxis.
• Pharmacodynamics :
  CNS agents of the 1,4 benzodiazepine class presumably exert their effects by binding at stereospecific receptors at several sites within the central nervous system. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis. Propranolol is a beta-adrenergic blocking agent that is used for treating high blood pressure.
• Dosage and administration :
  One tablet once daily.
• Contraindications :
  Contraindicated in patients with known sensitivity to this drug or other benzodiazepines. Alprazolam may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma. Patients with asthma or history of bronchospasm.
• Precautions and warnings :
  Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Dependence and withdrawal reactions, including seizures may occur. Should not drive or do anything that requires mental focus.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects: Pregnancy Category D. Benzodiazepines are known to be excreted in human milk. It should be assumed that alprazolam is as well. Chronic administration of diazepam to nursing mothers has been reported to cause their infants to become lethargic and to lose weight. Safety and effectiveness of alprazolam in individuals below 18 years of age have not been established.
• Drug interactions :
  The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol and other drugs which themselves produce CNS depression. Propranolol Hydrochloride: CYP2D6, CYP1A2 or CYP2C19 inhibitors increase propranolol plasma concentration. CYP1A2 inducers (phenytoin, phenobarbital) or CYP2C19 inducers (rifampin) decrease propranolol plasma concentration when co-administered. Corticosteroids: Patients on corticosteroids may be at increased risk of hypoglycaemia when administered along with propranolol.
• Adverse reactions :
  Confusion, memory impairment, slow heart rate, tiredness, and nightmare. It may also cause dizziness and sleepiness.
• Therapy Area :
  Anxiolytics