Anxit Tablets (Alprazolam).

• Composition :
  Each tablet contains Alprazolam 0.25 mg /0.5 mg /1.0 mg.
• Indications :
  Anxiolytic agent – Indicated in the treatment of anxiety associated with depression.
• Pharmacodynamics :
  CNS agents of the 1,4 benzodiazepine class presumably exert their effects by binding at stereospecific receptors at several sites within the central nervous system. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis.
• Dosage and administration :
  Treatment for patients with anxiety should be initiated with a dose of 0.25 to 0.5 mg given three times daily. The dose may be increased to achieve a maximum therapeutic effect, at intervals of 3 to 4 days, to a maximum daily dose of 4 mg, given in divided doses.
• Contraindications :
  Contraindicated in patients with known sensitivity to this drug or other benzodiazepines. Anxit may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma.
• Precautions and warnings :
  Concomitant use of benzodiazepines, including alprazolam, and opioids may result in profound sedation, respiratory depression, coma, and death. Drug dependence and withdrawal including seizures. Early morning anxiety and emergence of anxiety symptoms between doses of Anxit have been reported in patients with panic disorder taking prescribed maintenance doses of Anxit. Episodes of hypomania and mania have been reported in association with the use of Anxit in patients with depression.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects: Pregnancy Category D. Benzodiazepines are known to be excreted in human milk. It should be assumed that alprazolam is as well. Chronic administration of diazepam to nursing mothers has been reported to cause their infants to become lethargic and to lose weight. Safety and effectiveness of alprazolam in individuals below 18 years of age have not been established.
• Drug interactions :
  Alprazolam is primarily eliminated by metabolism via cytochrome P450 3A (CYP3A). Most of the interactions that have been documented with alprazolam are with drugs that inhibit or induce CYP3A4. The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol and other drugs which themselves produce CNS depression.
• Adverse reactions :
  Most frequent side effects of alprazolam are extension of its pharmacological effects eg, Depression, Sedation, somnolence, ataxia, memory impairment, dysarthria, dizziness, headache, Constipation, dry mouth, Fatigue, irritability.
• Therapy Area :
  Anxiolytics