Anxit 0.5 SR (Alprazolam).

• Composition :
  Each tablet contains Alprazolam 0.5mg SR.
• Indications :
  Short-term treatment of anxiety disorder, anxiety associated with depression and panic disorders.
• Pharmacodynamics :
  CNS agents of the 1,4 benzodiazepine class presumably exert their effects by binding at stereospecific receptors at several sites within the central nervous system. Their exact mechanism of action is unknown.
• Dosage and administration :
  Initial dose is 0.5 mg to 1mg per day. The suggested total daily dose ranges between 3 to 6 mg/day.
• Contraindications :
  Contraindicated in patients with known sensitivity to this drug or other benzodiazepines. Anxit may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma.
• Precautions and warnings :
  Drug dependence and withdrawal including seizures. Early morning anxiety and emergence of anxiety symptoms between doses of Anxit have been reported in patients with panic disorder taking prescribed maintenance doses of Anxit. Episodes of hypomania and mania have been reported in association with the use of Anxit in patients with depression.
• Use in pregnancy, lactation & pediatrics :
  Teratogenic Effects: Pregnancy Category D. Hence, not recommended during pregnancy. Anxit SR tablets are not intended to be used during lactation. Safety and effectiveness of alprazolam in individuals below 18 years of age have not been established.
• Drug interactions :
  The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression. Caution should be exercised if Anxit-SR tablets are to be combined with other psychotropic agents or anticonvulsant drugs. Alprazolam increases plasma concentration of imipramine and desipramine. Alprazolam should be avoided in patients who are receiving inhibitors of CYP3A such as ketoconazole, itraconazole, fluvoxamine, nefazodone and cimetidine, as these drugs increase the plasma concentration of itraconazole. Fluoxetine and oral contraceptives increase the plasma concentration of alprazolam and propoxyphene decreases the plasma concentration of alprazolam. Carbamazepine can increase alprazolam metabolism and therefore can decrease plasma levels of alprazolam.
• Adverse reactions :
  Most frequent side effects of alprazolam are extension of its pharmacological effects eg, depression, sedation, somnolence, ataxia, memory impairment, dysarthria, dizziness, headache, constipation, dry mouth, fatigue and irritability.
• Therapy Area :
  Anxiolytics