The composition is used for the treatment and management of schizophrenia and acute maniac episodes associated with bipolar disorders.
Risperidone works by antagonism of combination of dopamine Type 2 (D2 ) and serotonin Type 2 (5HT2) receptors; Trihexyphenidyl is an anticholinergic agent, which acts as a potent indirect dopamine agonist.
One tablet per day can be taken with or without food.
Contraindicated in patients with hypersensitivity to active ingredients or excipients in the formulation, Narrow angle glaucoma.
should be discontinued at the first sign of clinical symptoms of tardive dyskinesia and Neuroleptic Malignant Syndrome.
drug treatment should be avoided in pregnancy unless considered essential. It is not known whether this drug is excreted in human milk , should only be used if the expected benefit to the mother outweighs the potential risk to the infant. Safety and efficacy in pediatrics has not been established.
Risperidone- Effects of levodopa and dopamine agonists may be antagonized. Cimetidine and ranitidine increase the bioavailability of risperidone. Trihexyphenidyl: Cannabinoids, barbituates, opiates, and alcohol may have additive effects .
The most common adverse effects are somnolence fatigue, akathisia, hyperglycaemia, Constipation, dizziness, tiredness, blurred vision and dryness in mouth.